Root-canal obturation was done by lateral condensation, chloroform-dip and eucalyptol- dip technique in single rooted extracted maxillary teeth and apical leakage was studied at 3 and 21 days. It was found that lateral condensation showed less leakage at both 3 and 21 days period than both chloroform and eucalyptol dip techniques. In all the three techniques, leakages was found to increase with passage of time but the maximum increase was in the eucalyptol-dip technique and the increase was statistically highly significant

Human pulp reaction to iontophoretic application of NaF 2%, 4% and acidulated phosphate fluoride (APF) 1.23% was studied and compared with normal saline as control. The response was observed at 24 hours and 7 days. It was found that NaF 2% scored higher but not statistically significant over 4% NaF and 1.23% APF solutions in evoking favourable pulpal response.

Modified access preparation and X-Ray interpretation were used clinically to aid in the search for additional canals in the root of maxillary second premolars. In 90% of the cases, two canals were located and treated. Of these 33.33% had two separate apical foramen and 51.66% had two canals, joined at the apical 2/3rd or 1 /3rd. In 5% of the cases, two roots with two different canals were located and in only 10% of the cases, one canal was located.

The antimicrobial effect of 0.2% Chlorhexidine, 0.2% Ciprofloxacin and 0.5% metronidazole against root canal flora in vivo was studied with normal saline as a control in 100 anterior teeth. Each tooth was treated at five appointments. Aerobic and anaerobic culture test evaluation was done on different appointment. It was observed that 0.2% Ciprofloxacin ws more effective against aerobic bacteria followed by 0.2% Chlorhexidine and 0.5% Metronidazole whereas 0.5% Metronidazole was more effective against anerobic bacteria. 0.2% Chlorhexidine and 0.2% Ciprofloxacin were found to be equally effective against anaerobes.