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Year : 1999  |  Volume : 11  |  Issue : 1  |  Page : 2-7

Role of virulence in periapical lesions

1 Chief, Endodontics section and Director of the Endodontic Residency Program, Veterans Administration Medical Center, Long Beach, California and Professor of Endodontics, Loma Linda School of Dentistry, Loma Linda, California, USA
2 Former Endodontic Resident, Veterans Administration Medical Center, Long Beach, California Currently in private practice limited to Endodontics, Fresno, California, USA
3 Professor and acting Chairman, Department of Endodontics, The Hebrew University-Hadassah Faculty of Dental Medicine, Jerusalem, Israel
4 Endodontic Resident, Veterans Administration Medical Center, Long Beach, California, USA

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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0970-7212.347450

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To understand the pathology of peri-apical infection and causes of endodontic treatment failures despite reasonably good endodontic treatment, an experimental animal study was undertaken. The results showed that depending on the virulence of microorganism involved, they can get past the apical foramen into the peri-apical tissues and not only survive there but can also reproduce. This can lead to failure of endodontic treatment, since now the infection is beyond the apical foramen and not amenable to debridement and disinfection procedures confined within the root canal space.

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